FORMULATION AND EVALUATION OF BILAYER TABLETS OF EZETIMIBE AND METFORMIN HCL
BILAYER TABLETS FORMULATION AND EVALUATION OF BILAYER TABLETS OF EZETIMIBE AND METFORMIN HCL N.S.V. SUSHMA ABSTRACT: Tablets are the unit solid dosage forms. Bi-layered tablets are one of the extended-release tablets. Metformin HCl belongs to this category of tablets which was prepared by using hydrophilic matrix polymers such as HPMC K15M, HPMC K4M, HPMC K100M, and Ezetimibe as immediate-release layer tablet. The combination of Ezetimibe and Metformin Hcl is used for the treatment of TYPE-II DIABETES MELLITUS which is non-insulin dependent. Drug release from the matrix was found to decrease the increase in polymer concentration. According to the angle of repose, bulk density, tapered density, and compressibility index results show that the formulation is suitable for wet granulation. The drug release kinetics of the optimized bi-layered tablets corresponding best to Kornsmeyer-Peppas model and the drug release mechanism as per the ‘n’ value of Kornsmeyer-Peppas