Articles and journals

Preparedness of India - COVID-19 N S V SUSHMA ADITYA COLLEGE OF PHARMACY Underinvestment in public, the health care system poses a challenge to India,s COVID-19 containment plans. The death toll due to coronavirus disease 2019 in India was of 6929 as of June 7, 2020. Since March 24, India has been under a nationwide lockdown, now it has been slightly modified by the government, to curb the spread of the virus. India is now among the worst-hit countries, but before it is not. But its grossly under-funded and patchy public health system, with huge variations between different states, poses special challenges for the country,s disease containment strategy. Over the past few weeks, there have been several reported instances in patients trying to free isolation wards in government hospitals and hide travel history. Many with exposure to suspected cases of COVID-19 and infected persons have also tried to dodge the mandatory home quarantine. Quarantine refers to t

BILAYER TABLETS FORMULATION AND EVALUATION OF BILAYER TABLETS OF EZETIMIBE AND METFORMIN HCL   N.S.V. SUSHMA   ABSTRACT:   Tablets are the unit solid dosage forms. Bi-layered tablets are one of the extended-release tablets. Metformin HCl belongs to this category of tablets which was prepared by using hydrophilic matrix polymers such as HPMC K15M, HPMC K4M, HPMC K100M, and Ezetimibe as immediate-release layer tablet.   The combination of Ezetimibe and Metformin Hcl is used for the treatment of TYPE-II DIABETES MELLITUS which is non-insulin dependent. Drug release from the matrix was found to decrease the increase in polymer concentration. According to the angle of repose, bulk density, tapered density, and compressibility index results show that the formulation is suitable for wet granulation. The drug release kinetics of the optimized bi-layered tablets corresponding best to Kornsmeyer-Peppas model and the drug release mechanism as per the ‘n’ value of Kornsmeyer-Peppas